Uno

While driving through Hart County, you might spot this cryptic road sign for Uno, Kentucky,

Supposedly its name is intended to mean "You Know" which, further supposedly, refers to the area's once-booming illicit moonshine industry. According to Wikipedia, another name for the town is Clearpoint, which supposedly really means "clear pint", as in moonshine. (I am deeply skeptical, however, of all fanciful local-lore retconned explanations of the name origins of small towns, which rarely turn out to be true.)

One thing we do know for sure is that the famous Smith's Country Hams got its start in Uno. Though that original store no longer exists, their Cave City location is still going strong.